Rana is from Gadarwara, Madhya Pradesh state. He was then known as Ashutosh Neekhra. He spent his childhood in Gadarwara where he finished his primary school. He used to play the role of Ravana in the city Ramleela.
He went to the National School of Drama, New Delhi and studied acting.
He started his career with the television serial Swabhimaan, followed by serials like, Farz, Sazish, Kabhi Kabhi, Waris and anchoring the TV show, Baazi Kiski. He also hosted Sarkaar Ki Duniya, a reality show. Currently, in 2010 he is working in a Star Plus show Kaali- Ek Agnipariksha, where he plays a negative role, Thakral.
He became known in Indian Cinema after his movie Dushman where he played a cold blooded murderer and psychopath killer. He is mostly given roles of antagonists in movies, particularly that of a killer. And in some movies he played supporting roles. He has acted in South Indian films, and is known as “Jeeva” in the South Indian Film Industry. He frequently appears in Mahesh Bhatt’s films.
He is married to Renuka Shahane, an actress in Mumbai. They have two sons named Shauryaman and Satyendra. His native language is Bundeli dialect of Hindi and he speaks fluent Urdu, English, Telugu and Marathi.